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KMID : 0361419970210020390
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Journal of Korean Academy of Rehabilitation Medicine
1997 Volume.21 No. 2 p.390 ~ p.398
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Effects of Botulinum Toxin A Treatment in Cerebral Palsy
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Abstract
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The purpose of this study is to evaluate the effects of intramuscular botulinum toxin A injection in cerebral palsy. We studied 25 children with cerebral palsy(age 3 to 20 years old). Among them, 14 children were spastic diplegia; were athetoid
quadriplegia; 3 were spastic hemiplegia; and were mixed type9spasticity and athetosis). Botulinum toxin A was injected into the target muscle groups with electromyographic guidance. The dose was calculated in unit/body weight basis. Followup
assessments were at 1 and 3 months after injection. After injection, 11 out of 16 children(68.8%) had a one-level improvement in ambulatory status. The passive range of joint motion increased significantly after injection. Modified Ashworth scale
decreased significantly after injection. In 23 out of 25 children, there were a significant increase of the mean GMFM(gross motor function measure) total score and mean GMFM scores for all dimensions at three months after injection. There were
the
distant effects after injection diplegia. In conclusion, botulinum toxin A tretment would improve the motor function and ambulatory status in cerebral palsy by reducing hypertonicity, spasticity, dynamic contracture and athetoid movement.
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KEYWORD
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